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Select item 60239131.

Live cell imaging reveals focal adhesions mechanoresponses in mammary epithelial cells under sustained equibiaxial stress

Lorena Sigaut, Catalina von Bilderling, Micaela Bianchi, Juan Eduardo Burdisso, Laura Gastaldi, Lía Isabel Pietrasanta

Sci Rep. 2018; 8: 9788. Published online 2018 Jun 28. doi: 10.1038/s41598-018-27948-3

PMCID:: PMC6023913

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Select item 84063052.

Campylobacter jejuni Triggers Signaling through Host Cell Focal Adhesions To Inhibit Cell Motility

Courtney M. Klappenbach, Nicholas M. Negretti, Jesse Aaron, Teng-Leong Chew, Michael E. Konkel

mBio. 2021 Jul-Aug; 12(4): e01494-21. Published online 2021 Aug 24. doi: 10.1128/mBio.01494-21

PMCID:: PMC8406305

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Select item 75862173.

A post-invasion role for Chlamydia type III effector TarP in modulating the dynamics and organization of host cell focal adhesions

António T. Pedrosa, Korinn N. Murphy, Ana T. Nogueira, Amanda J. Brinkworth, Tristan R. Thwaites, Jesse Aaron, Teng-Leong Chew, Rey A. Carabeo

J Biol Chem. 2020 Oct 23; 295(43): 14763–14779. Published online 2020 Aug 25. doi: 10.1074/jbc.RA120.015219

PMCID:: PMC7586217

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Select item 56942134.

Activation of Rho-kinase and focal adhesion kinase regulates the organization of stress fibers and focal adhesions in the central part of fibroblasts

Kazuo Katoh

PeerJ. 2017; 5: e4063. Published online 2017 Nov 15. doi: 10.7717/peerj.4063

PMCID:: PMC5694213

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Select item 57950085.

Diverse patterns of molecular changes in the mechano-responsiveness of focal adhesions

Rahuman S. Malik-Sheriff, Sarah Imtiaz, Hernán E. Grecco, Eli Zamir

Sci Rep. 2018; 8: 2187. Published online 2018 Feb 1. doi: 10.1038/s41598-018-20252-0

PMCID:: PMC5795008

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Select item 49826586.

Highly Multiplexed Imaging Uncovers Changes in Compositional Noise within Assembling Focal Adhesions

Jana Harizanova, Yessica Fermin, Rahuman S. Malik-Sheriff, Jakob Wieczorek, Katja Ickstadt, Hernán E. Grecco, Eli Zamir

PLoS One. 2016; 11(8): e0160591. Published online 2016 Aug 12. doi: 10.1371/journal.pone.0160591

PMCID:: PMC4982658

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Select item 109579757.

Focal adhesions contain three specialized actin nanoscale layers

Reena Kumari, Katharina Ven, Megan Chastney, Shrikant B. Kokate, Johan Peränen, Jesse Aaron, Konstantin Kogan, Leonardo Almeida-Souza, Elena Kremneva, Renaud Poincloux, Teng-Leong Chew, Peter W. Gunning, Johanna Ivaska, Pekka Lappalainen

Nat Commun. 2024; 15: 2547. Published online 2024 Mar 21. doi: 10.1038/s41467-024-46868-7

PMCID:: PMC10957975

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MAGI1 localizes to mature focal adhesion and modulates endothelial cell adhesion, migration and angiogenesis

Begoña Alday-Parejo, Kedar Ghimire, Oriana Coquoz, Gioele W. Albisetti, Luca Tamò, Jelena Zaric, Jimmy Stalin, Curzio Rüegg

Cell Adh Migr. 2021; 15(1): 126–139. Published online 2021 May 6. doi: 10.1080/19336918.2021.1911472

PMCID:: PMC8115569

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Select item 86149059.

A Layered View on Focal Adhesions

Karin Legerstee, Adriaan B. Houtsmuller

Biology (Basel) 2021 Nov; 10(11): 1189. Published online 2021 Nov 16. doi: 10.3390/biology10111189

PMCID:: PMC8614905

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Select item 945386410.

An evolutionary and physiological perspective on cell-substrate adhesion machinery for cell migration

Julio C. Fierro Morales, Qian Xue, Minna Roh-Johnson

Front Cell Dev Biol. 2022; 10: 943606. Published online 2022 Aug 25. doi: 10.3389/fcell.2022.943606

PMCID:: PMC9453864

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FAK Structure and Regulation by Membrane Interactions and Force in Focal Adhesions

Paula Tapial Martínez, Pilar López Navajas, Daniel Lietha

Biomolecules. 2020 Feb; 10(2): 179. Published online 2020 Jan 24. doi: 10.3390/biom10020179

PMCID:: PMC7072507

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Select item 920396312.

Cells Dynamically Adapt to Surface Geometry by Remodeling Their Focal Adhesions and Actin Cytoskeleton

Aysegul Dede Eren, Amy W. A. Lucassen, Urandelger Tuvshindorj, Roman Truckenmüller, Stefan Giselbrecht, E. Deniz Eren, Mehmet Orhan Tas, Phanikrishna Sudarsanam, Jan de Boer

Front Cell Dev Biol. 2022; 10: 863721. Published online 2022 Jun 3. doi: 10.3389/fcell.2022.863721

PMCID:: PMC9203963

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Phosphorylation of GMFγ by c-Abl Coordinates Lamellipodial and Focal Adhesion Dynamics to Regulate Airway Smooth Muscle Cell Migration

Brennan D. Gerlach, Kate Tubbesing, Guoning Liao, Alyssa C. Rezey, Ruping Wang, Margarida Barroso, Dale D. Tang

Am J Respir Cell Mol Biol. 2019 Aug; 61(2): 219–231. doi: 10.1165/rcmb.2018-0352OC

PMCID:: PMC6670026

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Select item 553173514.

The phospho–caveolin-1 scaffolding domain dampens force fluctuations in focal adhesions and promotes cancer cell migration

Fanrui Meng, Sandeep Saxena, Youtao Liu, Bharat Joshi, Timothy H. Wong, Jay Shankar, Leonard J. Foster, Pascal Bernatchez, Ivan R. Nabi

Mol Biol Cell. 2017 Aug 1; 28(16): 2190–2201. doi: 10.1091/mbc.E17-05-0278

PMCID:: PMC5531735

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Select item 863681915.

Profiling the responsiveness of focal adhesions of human cardiomyocytes to extracellular dynamic nano-topography

Huaiyu Shi, Xiangjun Wu, Shiyang Sun, Chenyan Wang, Zacharias Vangelatos, Ariel Ash-Shakoor, Costas P. Grigoropoulos, Patrick T. Mather, James H. Henderson, Zhen Ma

Bioact Mater. 2022 Apr; 10: 367–377. Published online 2021 Aug 28. doi: 10.1016/j.bioactmat.2021.08.028

PMCID:: PMC8636819

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Select item 761327816.

Local synthesis of the phosphatidylinositol-3,4-bisphosphate lipid drives focal adhesion turnover

York Posor, Charis Kampyli, Benoit Bilanges, Sushila Ganguli, Philipp A. Koch, Alexander Wallroth, Daniele Morelli, Michalina Jenkins, Samira Alliouachene, Elitza Deltcheva, Buzz Baum, Volker Haucke, Bart Vanhaesebroeck

Dev Cell. 2022 Jul 25; 57(14): 1694–1711.e7. doi: 10.1016/j.devcel.2022.06.011

PMCID:: PMC7613278

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Select item 992993217.

Lack of Paxillin phosphorylation promotes single-cell migration in vivo

Qian Xue, Sophia R.S. Varady, Trinity Q Alaka’i Waddell, Mackenzie R. Roman, James Carrington, Minna Roh-Johnson

J Cell Biol. 2023 Mar 6; 222(3): e202206078. Published online 2023 Feb 1. doi: 10.1083/jcb.202206078

PMCID:: PMC9929932

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Identification of a novel type of focal adhesion remodelling via FAK/FRNK replacement, and its contribution to cancer progression

Masatsune Tsujioka, Keisuke Miyazawa, Masaki Ohmuraya, Yoichi Nibe, Tetsuya Shirokawa, Haruko Hayasaka, Tsunekazu Mizushima, Takeshi Fukuma, Shigeomi Shimizu

Cell Death Dis. 2023 Apr; 14(4): 256. Published online 2023 Apr 8. doi: 10.1038/s41419-023-05774-4

PMCID:: PMC10082854

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Correlation of cellular traction forces and dissociation kinetics of adhesive protein zyxin revealed by multi-parametric live cell microscopy

Lorena Sigaut, Micaela Bianchi, Catalina von Bilderling, Lía Isabel Pietrasanta

PLoS One. 2021; 16(5): e0251411. Published online 2021 May 11. doi: 10.1371/journal.pone.0251411

PMCID:: PMC8112686

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Select item 833563320.

Basement membrane regulates fibronectin organization using sliding focal adhesions driven by a contractile winch

Jiaoyang Lu, Andrew D. Doyle, Yoshinari Shinsato, Shaohe Wang, Molly A. Bodendorfer, Minhua Zheng, Kenneth M. Yamada

Dev Cell. Author manuscript; available in PMC 2021 Aug 4.

Published in final edited form as: Dev Cell. 2020 Mar 9; 52(5): 631–646.e4. Published online 2020 Jan 30. doi: 10.1016/j.devcel.2020.01.007

PMCID:: PMC8335633

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PMC Images search for focal contact

Figure 2.

Schematics of the protein components of the focal contact (left) and hemidesmosome (right).

Focal Contact and Hemidesmosomal Proteins in Keratinocyte Migration and Wound Repair

Adv Wound Care (New Rochelle). 2014 Mar 1;3(3):247-263.
Fig. 2

Still images for the dynamics of hemidesmosomal proteins and focal contact proteins in live migrating keratinocytes.

Hemidesmosomes and focal contact proteins: Functions and cross-talk in keratinocytes, bullous diseases and wound healing

J Dermatol Sci. ;62(1):1-7.
Figure 2

ST rapidly reduces focal contact size in PMC42-LA cells. Cells were treated for 3 h with 10 ng/ml EGF, 40 nM ST or both, fixed and immunostained for the focal contact specific protein paxillin (b+w, green in enlarged images) and F-actin (red). Magnification: ×63, scale bar = 10 μM.

Staurosporine augments EGF-mediated EMT in PMC42-LA cells through actin depolymerisation, focal contact size reduction and Snail1 induction – A model for cross-modulation

BMC Cancer. 2009;9:235-235.
Figure 1.

A schematic of the edge of a wound-healing epidermis. On the left, a keratinocyte in an unwounded region adheres to the laminin-332 (LM332) in the basement membrane (BM) in part through a keratin-associated hemidesmosome (HD) and possibly, an actin-interacting focal contact (FC). The HD is targeted by kinases and proteases (arrow) in cells at the wound margin (middle cell). Cells that leave the BM move over a provisional matrix composed of fibronectin (depicted as fibrils) and laminin-332. Focal contact and hemidesmosomal integrins interact with this matrix and likely regulated the directed migration of the motile keratinocytes. The box indicates the key for α₃β₁ and α₆β₄ integrin heterodimers.

Focal Contact and Hemidesmosomal Proteins in Keratinocyte Migration and Wound Repair

Adv Wound Care (New Rochelle). 2014 Mar 1;3(3):247-263.